SENP2
Description
The SENP2 (SUMO specific peptidase 2) is a protein-coding gene located on chromosome 3.
Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene. SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of protease enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species. [supplied by OMIM] SENP2 has been shown to interact with NUP153.
SENP2 is a protease that plays a crucial role in the SUMO pathway. It performs two essential functions: 1) Processing SUMO propeptides (SUMO1, SUMO2, and SUMO3) by hydrolyzing an alpha-linked peptide bond at their C-terminus, resulting in their mature forms. 2) Deconjugating SUMO1, SUMO2, and SUMO3 from target proteins by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. These functions are essential for regulating SUMOylation, a post-translational modification process involving the attachment of SUMO proteins to target proteins. Furthermore, SENP2 has been implicated in the Wnt pathway, possibly by down-regulating CTNNB1 levels. It also plays a crucial role in adipogenesis by desumoylating and stabilizing CEBPB. Additionally, SENP2 is involved in the regulation of the cGAS-STING pathway by desumoylating CGAS and STING1 during the late phase of viral infection.
SENP2 is also known as AXAM2, SMT3IP2.
Associated Diseases
- lysosomal storage disease
- type 2 diabetes mellitus
- endometrial cancer
- esophageal cancer
- benign adult familial myoclonic epilepsy
