SGCZ
Description
The SGCZ (sarcoglycan zeta) is a protein-coding gene located on chromosome 8.
Sarcoglycan zeta, also known as SGCZ, is a protein encoded by the SGCZ gene in humans. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are transmembrane proteins with a short intracellular domain, a single transmembrane region, and a large extracellular domain. They are all N-glycosylated and have a carboxyl-terminal cluster with conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which connects the inner cytoskeleton to the extracellular matrix. Reduced levels of zeta-sarcoglycan are found in mouse models of muscular dystrophy, and SGCZ is a component of the vascular smooth muscle sarcoglycan complex. This suggests that SGCZ may play a role in the pathogenesis of muscular dystrophy.
SGCZ forms part of the sarcoglycan complex, a subcomplex within the dystrophin-glycoprotein complex. This complex acts as a bridge between the F-actin cytoskeleton and the extracellular matrix. SGCZ is believed to contribute to the stability of striated muscle membranes.
SGCZ is also known as ZSG1.
