SHROOM3
Description
The SHROOM3 (shroom family member 3) is a protein-coding gene located on chromosome 4.
The human gene SHROOM3 encodes a protein called Shroom3, also known as Shroom-related protein. This protein belongs to the Shroom-related protein family and contains a PDZ domain. It's believed to play a role in regulating cell shape within specific tissues. Mutations in the SHROOM3 gene have been linked to heterotaxy, a condition characterized by abnormal positioning of organs. A similar protein found in mice is essential for normal development of the neural tube, eyes, and gut.
SHROOM3 plays a crucial role in shaping the neuroepithelium during the formation of the neural tube. It achieves this by inducing apical constriction in epithelial cells, a process facilitated by the accumulation of F-actin and myosin II at the apical surface, potentially through bundling stress fibers. Additionally, SHROOM3 influences cell elongation in the apicobasal direction by redistributing gamma-tubulin and orchestrating the assembly of organized apicobasal microtubule arrays.
SHROOM3 is also known as APXL3, MSTP013, SHRM, ShrmL.
