SLC22A15
Description
The SLC22A15 (solute carrier family 22 member 15) is a protein-coding gene located on chromosome 1.
SLC22A15 is a protein involved in transporting a variety of molecules across cell membranes. These molecules include drugs, toxins, hormones, neurotransmitters, and cellular metabolites. SLC22A15 belongs to a family of proteins known as organic ion transporters or amphiphilic solute facilitators (ASFs).
SLC22A15 is a transporter that moves various molecules across cell membranes, including amino acids, their derivatives, carnitine, acetylcarnitine, glycine betaine, ergothioneine, carnosine, and thiamine. It has a preference for zwitterionic substrates and can transport cations with an indole skeleton. It does not transport agmatine. SLC22A15 may operate through sodium-coupled symport or facilitated diffusion, but the precise mechanism is not yet fully understood.
SLC22A15 is also known as FLIPT1, PRO34686.
Associated Diseases
- Brugada syndrome
- familial atrial fibrillation
- ventricular fibrillation, paroxysmal familial, type 1
- cardiomyopathy, dilated, 2I
- familial sick sinus syndrome
- arrhythmogenic right ventricular dysplasia 1
- long QT syndrome 12
- catecholaminergic polymorphic ventricular tachycardia
- catecholaminergic polymorphic ventricular tachycardia 4
- Brugada syndrome 1
- long QT syndrome 5
- ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome
