SLC23A1
Description
The SLC23A1 (solute carrier family 23 member 1) is a protein-coding gene located on chromosome 5.
SLC23A1 is a protein involved in vitamin C absorption and distribution throughout the body. It's one of two essential transporters required for this process. SLC23A1 is active in bulk vitamin C transport, particularly in epithelial surfaces. The gene encoding this protein was previously known as SLC23A2.
SLC23A1 is a sodium-dependent transporter that facilitates the uptake of vitamin C (ascorbate) into cells. It requires two sodium ions for each ascorbate molecule, making it an electrogenic transporter. SLC23A1 also exhibits ancestral activity towards nucleobases like urate, acting as a low-affinity, high-capacity sodium-urate cotransporter. This function suggests a potential role in regulating serum urate levels by reabsorbing urate in the kidneys.
SLC23A1 is also known as SLC23A2, SVCT1, YSPL3.
Associated Diseases
- cystinuria
- hyperdibasic aminoaciduria type 1
- hereditary renal hypouricemia
- Dent disease
- saccharopinuria
- 5-oxoprolinase deficiency
- hyperprolinemia type 2
