SLC28A3
Description
The SLC28A3 (solute carrier family 28 member 3) is a protein-coding gene located on chromosome 9.
SLC28A3 is a sodium-dependent nucleoside transporter that exhibits selectivity for both pyrimidine and purine nucleosides. It is involved in the homeostasis of endogenous nucleosides, including thymidine, inosine, and uridine. The transporter functions as a concentrative Na(+)-nucleoside cotransporter, with a 2:1 sodium/nucleoside ratio, and belongs to the N3/cib subtype of nucleoside transport systems. SLC28A3 is capable of transporting a range of nucleoside analogs, including gemcitabine, AZT, ribavirin, and 3-deazauridine.
SLC28A3 is also known as CNT3.
Associated Diseases
- neutropenia, severe congenital, 2, autosomal dominant
- X-linked severe congenital neutropenia
- neutropenia, severe congenital, 1, autosomal dominant
- substance abuse
