SLC36A1
Description
The SLC36A1 (solute carrier family 36 member 1) is a protein-coding gene located on chromosome 5.
The SLC36A1 gene encodes a protein called proton-coupled amino acid transporter 1. This protein belongs to the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family and acts as a proton-dependent transporter for small amino acids. The SLC36A1 gene is located on chromosome 5q33.1, clustered with other related genes.
This protein is an electrogenic proton/amino acid symporter that preferentially transports small, nonpolar L-amino acids, their D-enantiomers, and certain amino acid derivatives like 4-aminobutanoate/GABA. It is thought to be involved in the efflux of neutral amino acids from lysosomes after protein breakdown. Additionally, it may play a role in determining exocytosis sites in neurons.
SLC36A1 is also known as Dct1, LYAAT1, PAT1, TRAMD3.
Associated Diseases
- Parkinson disease
- lysosomal storage disease
- Alzheimer disease
- multiple sclerosis
- familial visceral myopathy
