SOCS4
Description
The SOCS4 (suppressor of cytokine signaling 4) is a protein-coding gene located on chromosome 14.
Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene. It contains a SH2 domain and a SOCS BOX domain, classifying it as a member of the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI). SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
SOCS family proteins are part of a negative feedback system that regulates cytokine signaling. They act as substrate-recognition components of a SCF-like E3 ubiquitin-protein ligase complex, leading to ubiquitination and subsequent degradation of target proteins. This protein specifically inhibits EGF signaling by promoting the degradation of the Tyr-phosphorylated EGF receptor.
SOCS4 is also known as SOCS7.
Associated Diseases
- common variable immunodeficiency
- severe combined immunodeficiency due to CTPS1 deficiency
- immunodeficiency 18
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- schizophrenia
- severe combined immunodeficiency due to CARD11 deficiency
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- severe combined immunodeficiency due to CORO1A deficiency
- combined immunodeficiency with skin granulomas
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive
- immunodeficiency, common variable, 4
- agammaglobulinemia 7, autosomal recessive
- combined immunodeficiency due to moesin deficiency
- severe combined immunodeficiency due to LAT deficiency
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- severe combined immunodeficiency due to IKK2 deficiency
