SPATA2
Description
The SPATA2 (spermatogenesis associated 2) is a protein-coding gene located on chromosome 20.
Spermatogenesis-associated protein 2 is a protein that in humans is encoded by the SPATA2 gene.
SPATA2, also known as Spermatogenesis-associated protein 2, acts as a bridging factor that facilitates the recruitment of CYLD (a deubiquitinase) to the LUBAC complex. This interaction is crucial for regulating TNF-alpha-induced necroptosis, a form of programmed cell death. SPATA2 directly binds to both RNF31/HOIP (the catalytic subunit of LUBAC) and CYLD, effectively bridging the two components. This bridging function enables the recruitment of CYLD to the TNF-R1 signaling complex (TNF-RSC). Furthermore, SPATA2 plays a vital role in activating the 'Met-1' (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. By promoting the 'Met-1'-linked deubiquitination of RIPK1 (a key kinase in necroptosis) by CYLD, SPATA2 exerts control over RIPK1's kinase activity and ultimately influences TNF-alpha-induced necroptosis.
SPATA2 is also known as PD1, PPP1R145, tamo.
Associated Diseases
- systemic lupus erythematosus
- type 2 diabetes mellitus
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 63
- spinocerebellar ataxia type 32
- spermatogenic failure 25
- congenital bilateral absence of vas deferens
- spermatogenic failures 50
- isochromosomy Yp
- spermatogenic failure 65
- spermatogenic failure, X-linked, 2
- spermatogenic failure, X-linked, 3
- spermatogenic failure 40
- spermatogenic failure 7
