SRSF10

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Description

The SRSF10 (serine and arginine rich splicing factor 10) is a protein-coding gene located on chromosome 1.

SRSF10, also known as 40 kDa SR-repressor protein, FUS-interacting serine-arginine-rich protein 1, Splicing factor SRp38, Splicing factor, arginine/serine-rich 13A, TLS-associated protein with Ser-Arg repeats, and TLS-associated serine-arginine protein, is a splicing factor that acts as a general repressor of pre-mRNA splicing in its dephosphorylated form. It interferes with the U1 snRNP 5'-splice recognition of SNRNP70 and is required for splicing repression in M-phase cells and after heat shock. SRSF10 also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Its interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. SRSF10 may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. The phosphorylated form of SRSF10 interacts with TRA2B/SFRS10, while the dephosphorylated form interacts with SNRNP70. Isoform 1 and 3 interact with FUS C-terminus. SRSF10 also interacts with YTHDC1, leading to inhibit its RNA-binding activity.

SRSF10 acts as a general repressor of pre-mRNA splicing when dephosphorylated. It also promotes exon skipping during alternative splicing. SRSF10 interacts with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, preventing SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibition of exon skipping. SRSF10 may be involved in the regulation of alternative splicing in neurons, with isoform 1 acting as a positive regulator and isoform 3 acting as a negative regulator.

SRSF10 is also known as FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2.

Associated Diseases

• left ventricular noncompaction
• cancer
• dilated cardiomyopathy 1AA
• hypertrophic cardiomyopathy 4
• ventricular septal defect 1
• cardiomyopathy, dilated, 2H
• cardiomyopathy, dilated, 2G
• familial idiopathic dilatation of the right atrium
• left ventricular noncompaction 10
• congenital Gerbode defect