STARD7
Description
The STARD7 (StAR related lipid transfer domain containing 7) is a protein-coding gene located on chromosome 2.
STARD7, or Gestational trophoblastic tumor gene-1 (GTT1), is a lipid transporter that specifically moves phosphatidylcholine between cell membranes. It's found in the cell's cytoplasm and associated with mitochondria. When there's too much STARD7 in a cell, the levels of phosphatidylcholine in the mitochondria increase. There are higher amounts of STARD7 in tumor cells compared to normal cells, suggesting a role in cell growth. There are two forms of STARD7: StarD7-I and StarD7-II. StarD7-I is 295 amino acids long and has an extra 75 amino acids at the beginning, which guide it to the outer membrane of the mitochondria. STARD7 has a StAR-related transfer domain (START), which gives it its name. It belongs to a group of START proteins called the StarD2 subfamily, which mostly transport phosphatidylcholine. It shares about 25% of its sequence with StarD2.
STARD7 is also known as ADCME, BAFME2, FAME, FAME2, FCMTE2, GTT1.
