STC1
Description
The STC1 (stanniocalcin 1) is a protein-coding gene located on chromosome 8.
Stanniocalcin-1 is a glycoprotein that is a homologue of a hormone, stanniocalcin, found in bony fish. In humans, it is encoded by the STC1 gene. This gene produces a secreted, homodimeric glycoprotein that is present in many tissues. It may have autocrine or paracrine functions. Its only known molecular function is a SUMO E3 ubiquitin ligase activity in the SUMOylation cycle. STC1 interacts with many proteins in different parts of the cell. The N-terminal region of STC1 interacts with other proteins, including SUMO1. Studies show that STC1 exists as an anti-parallel homodimer in solution. The cysteine at position 202 is responsible for dimer formation. The gene has a 5' UTR rich in CAG trinucleotide repeats. The protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C on its serine residues. STC1 may play a role in regulating renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis.
STC1 is also known as STC.
