STK10
Description
The STK10 (serine/threonine kinase 10) is a protein-coding gene located on chromosome 5.
STK10 is a human gene encoding a serine/threonine-protein kinase belonging to the Ste20 family. It shares similarities with known polo-like kinase kinases. STK10 can associate with and phosphorylate polo-like kinase 1. Overexpression of a kinase-dead version of STK10 disrupts normal cell cycle progression. STK10 negatively regulates interleukin 2 expression in T-cells through the mitogen activated protein kinase kinase 1 pathway.
STK10 is a serine/threonine-protein kinase that plays a role in regulating lymphocyte migration. It phosphorylates MSN and potentially PLK1, contributing to the regulation of lymphocyte movement by mediating the phosphorylation of ERM proteins, including MSN. STK10 acts as a negative regulator of MAP3K1/MEKK1. Additionally, it may function as a cell cycle regulator by acting as a polo kinase kinase, phosphorylating PLK1 in vitro. However, in vivo evidence is required to confirm this role. [ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442]
STK10 is also known as LOK, PRO2729.
Associated Diseases
- colorectal cancer
- hyper-IgM syndrome type 3
- severe combined immunodeficiency due to CARD11 deficiency
- cancer
