STK33
Description
The STK33 (serine/threonine kinase 33) is a protein-coding gene located on chromosome 11.
STK33, or Serine/threonine kinase 33, is a protein encoded by the STK33 gene in humans. It was identified as a synthetic lethal gene in cell lines that depend on the KRAS gene. STK33 is being investigated as a potential target for reversible male contraceptives, and the inhibitor CDD-2807 has shown promising results in mice.
STK33 is a serine/threonine protein kinase that phosphorylates VIME, potentially playing a role in regulating the dynamic behavior of the intermediate filament cytoskeleton. While not essential for the survival of KRAS-dependent AML cell lines, it interacts with VIME.
STK33 is also known as SPGF93.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- cancer
- spermatogenic failure 19
- spermatogenic failure 43
- spermatogenic failure 45
- spermatogenic failure 49
- spermatogenic failure 46
