STMN2
Description
The STMN2 (stathmin 2) is a protein-coding gene located on chromosome 8.
Stathmin-2 is a protein encoded by the STMN2 gene in humans. It is a neuronal growth-associated protein with significant amino acid sequence similarity to stathmin. It interacts with RGS6.
Stathmin-2 regulates microtubule stability. Phosphorylation by MAPK8 stabilizes microtubules, impacting neurite length in cortical neurons. During brain development, it slows down the transition from a multipolar stage and hinders radial migration from the ventricular zone.
STMN2 is also known as SCG10, SCGN10.
Associated Diseases
- schizophrenia
- Charcot-Marie-Tooth disease type 1A
- schizophrenia 15
- Phelan-McDermid syndrome
- amyotrophic lateral sclerosis type 11
- Hirschsprung disease
