SYMPK
Description
The SYMPK (symplekin scaffold protein) is a protein-coding gene located on chromosome 19.
Symplekin is a protein encoded by the SYMPK gene in humans. It resides in the nucleus and functions in the regulation of polyadenylation, promoting gene expression. Symplekin forms a complex with polyadenylation machinery components, acting as a scaffold for recruiting regulatory factors. It is involved in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. Symplekin also localizes to the cytoplasmic plaques of tight junctions in certain cell types.
Symplekin plays a crucial role in the intricate process of pre-mRNA polyadenylation. It acts as a scaffold protein, orchestrating the assembly of a multi-protein complex responsible for the 3'-end processing of histone mRNAs. Notably, symplekin also features as a specific component of the tight junction plaque, although its presence may extend beyond these junctions. Additionally, symplekin exhibits a capacity to enhance the activity of the SSU72 phosphatase, further underscoring its diverse functional repertoire.
SYMPK is also known as Pta1, SPK, SYM.
