SYTL2
Description
The SYTL2 (synaptotagmin like 2) is a protein-coding gene located on chromosome 11.
Synaptotagmin-like 2, also known as SYTL2, is a human gene. The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.
SYTL2 isoform 1 functions as a RAB27A effector protein, playing a role in cytotoxic granule exocytosis in lymphocytes. It is crucial for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and facilitates the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
SYTL2 is also known as CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A.
Associated Diseases
- inflammatory bowel disease 30
- NK-cell enteropathy
- pyloric stenosis, infantile hypertrophic, 1
- chronic intestinal pseudoobstruction
- Alzheimer disease
