TIMM10B
Description
The TIMM10B (translocase of inner mitochondrial membrane 10B) is a protein-coding gene located on chromosome 11.
TIMM10B, also known as FXC1, is a protein involved in the import of proteins into mitochondria. It is part of a family of conserved proteins that form complexes within the mitochondrial intermembrane space.
TIMM10B is part of the TIM22 complex, a key component of mitochondrial protein import. This complex facilitates the insertion of multi-pass transmembrane proteins into the inner mitochondrial membrane. The TIM22 complex operates as a 'twin-pore' translocase, utilizing the membrane potential as its energy source. Within the TIM22 complex, TIMM10B may serve as a docking site for the soluble 70 kDa complex, a chaperone that guides target proteins through the mitochondrial intermembrane space.
TIMM10B is also known as FXC1, TIM10B, Tim9b.
Associated Diseases
- isolated asymptomatic elevation of creatine phosphokinase
- plasma fibronectin deficiency
- pentosuria
- myopathy due to calsequestrin and SERCA1 protein overload
- metabolic myopathy due to lactate transporter defect
- breast cancer
- COVID-19
