TMEM176B
Description
The TMEM176B (transmembrane protein 176B) is a protein-coding gene located on chromosome 7.
TMEM176B, also known as LR8, is a transmembrane protein encoded by the TMEM176B gene. It's believed to play a role in the maturation of dendritic cells.
Gene
- Location: Found on chromosome 7 (7q36.1), spanning 10,074 base pairs with 11 exons.
- Neighbors: TMEM176A and LOC105375566 are neighboring genes.
- Expression: Most highly expressed in the liver, followed by the kidney.
- Transcript Variants: Three isoforms (A, B, C) exist, with variants of isoforms A and C. Isoform A variant 1 has 1444 nucleotides encoding 270 amino acids.
Homology
- Paralogs: TMEM176A is a paralog of TMEM176B.
- Orthologs: TMEM176B has numerous orthologs in different species, including both close and distant relatives.
TMEM176B is also known as LR8, MS4B2.
