TMED4
Description
The TMED4 (transmembrane p24 trafficking protein 4) is a protein-coding gene located on chromosome 7.
P24 protein family is a group of transmembrane proteins that are major components of COPI and COPII-coated vesicles. The family is also known as EMP24/GP25L/p24 family and TMP21-like proteins. The latter naming was after transmembrane emp24 domain-containing protein 10 that was found in the human brain. It was claimed to block the beta-amyloid peptide, which is implicated in the pathogenesis of Alzheimer's disease.
== Function == p24 family proteins localize to the major organelles of the early secretory pathway: the endoplasmic reticulum and the Golgi apparatus, where they seem to be involved in trafficking between the two compartments. In yeast, all p24 family proteins can be removed, causing only a mild phenotype. However, in mammals at least some p24 proteins are essential for survival, e.g. removal of p24Ξ΄1 is lethal in mice. p24 family members have been implicated in the biogenesis of COPI and COPII-coated vesicles, transporting membrane-bound proteins through the secretory system, and forming the structure of the endoplasmic reticulum and Golgi.
== Distribution == Most p24 family proteins are widely expressed in various tissues.
TMED4 is also known as ERS25, GMP25iso, HNLF, p24a3, p24alpha3.
