TYW1B
Description
The TYW1B (tRNA-yW synthesizing protein 1 homolog B) is a protein-coding gene located on chromosome 7.
TYW1B is a component of the wybutosine biosynthesis pathway. Wybutosine is a modified guanine nucleotide with a unique tricyclic structure, located at the 3' position adjacent to the anticodon of eukaryotic phenylalanine tRNA. TYW1B catalyzes the formation of 4-demethylwyosine, an intermediate in wybutosine biosynthesis, by combining N-methylguanine with two carbon atoms from pyruvate.
TYW1B is also known as LINC00069, NCRNA00069, RSAFD2.
Associated Diseases
- hemoglobin E-beta-thalassemia syndrome
- hemoglobin D disease
- hemoglobin E disease
- dominant beta-thalassemia
- congenital dyserythropoietic anemia type 4
- saccharopinuria
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- cancer
- arterial disorder
