UBE2G1
Description
The UBE2G1 (ubiquitin conjugating enzyme E2 G1) is a protein-coding gene located on chromosome 17.
UBE2G1 is a gene that encodes a protein called ubiquitin-conjugating enzyme E2 G1. This protein is involved in attaching ubiquitin to other proteins, a process that targets them for degradation. UBE2G1 is part of a larger system involving E1 and E3 enzymes. This gene may play a role in the breakdown of muscle-specific proteins.
UBE2G1 accepts ubiquitin from the E1 complex and attaches it to other proteins. It can create both 'Lys-48' and 'Lys-63' linked polyubiquitin chains. This enzyme is likely involved in breaking down muscle-specific proteins and it is known to attach multiple ubiquitins to CYP3A4.
UBE2G1 is also known as E217K, UBC7, UBE2G.
Associated Diseases
- type 1 diabetes mellitus
- multiple epiphyseal dysplasia type 5
- refractive error
- hip dysplasia, Beukes type
- spondyloepiphyseal dysplasia tarda, Kohn type
- acromesomelic dysplasia 2C, Hunter-Thompson type
- multiple epiphyseal dysplasia type 4
- epiphyseal dysplasia, multiple, 6
- acromesomelic dysplasia 2B
- atelosteogenesis type III
- spondylometaphyseal dysplasia, Schmidt type
- pseudoachondroplasia
- Blount disease
- osteochondritis dissecans
- multiple epiphyseal dysplasia type 1
- multiple epiphyseal dysplasia, with severe proximal femoral dysplasia
- progressive pseudorheumatoid arthropathy of childhood
- coxopodopatellar syndrome
