UBXN10
Description
The UBXN10 (UBX domain protein 10) is a protein-coding gene located on chromosome 1.
UBXN10 is crucial for ciliogenesis, acting as a tethering factor that recruits the VCP/p97 protein to the intraflagellar transport complex B (IFT-B) in cilia. This interaction facilitates the movement of components along the cilia, essential for their proper function. UBXN10 belongs to a family of proteins that bind to VCP/p97 and likely contribute to its substrate specificity, directing the protein's activity towards specific targets.
UBXN10 is also known as UBXD3.
Associated Diseases
- isolated asymptomatic elevation of creatine phosphokinase
- plasma fibronectin deficiency
- pentosuria
- myopathy due to calsequestrin and SERCA1 protein overload
- metabolic myopathy due to lactate transporter defect
- carcinoma of liver and intrahepatic biliary tract
- ulnar-mammary syndrome
- pachyonychia congenita
- cancer
- liver hemangioma
