UNK
Description
The UNK (unk zinc finger) is a protein-coding gene located on chromosome 17.
UNK or UNK may refer to:
UNK is a sequence-specific RNA-binding protein that plays a crucial role in shaping the early structure of cortical neurons during embryonic development. It acts as a translation repressor, controlling a program that regulates cell morphology through translation. This ensures the proper formation of the nervous system. UNK achieves this by recognizing a specific sequence within target mRNAs, consisting of a UAG trimer followed by a U/A-rich motif. It's associated with polysomes, suggesting its involvement in protein synthesis.
UNK is also known as UNKEMPT, ZC3H5, ZC3HDC5.
Associated Diseases
- asthma
- hemoglobin D disease
- primary familial polycythemia due to EPO receptor mutation
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- hemoglobin E disease
