USP22
Description
The USP22 (ubiquitin specific peptidase 22) is a protein-coding gene located on chromosome 17.
Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17.
USP22 is a histone deubiquitinating enzyme that is part of the SAGA complex, a transcription regulatory histone acetylation complex. It catalyzes the deubiquitination of histones H2A and H2B, acting as a coactivator. USP22 is recruited to specific gene promoters by activators like MYC, where it is essential for transcription. It is also crucial for nuclear receptor-mediated transactivation and cell cycle progression.
USP22 is also known as USP3L.
Associated Diseases
- ovarian cancer
- lysosomal storage disease
- cancer
- breast cancer
- brain glioma
- Ehlers-Danlos syndrome, musculocontractural type
- cervical squamous intraepithelial neoplasia
