USP3
Description
The USP3 (ubiquitin specific peptidase 3) is a protein-coding gene located on chromosome 15.
USP3 is a hydrolase that removes ubiquitin from target proteins, including histones H2A and H2B. This deubiquitinating activity is crucial for proper progression through the cell cycle, specifically during the S phase and subsequent entry into mitosis. USP3 may also play a role in regulating the DNA damage response (DDR) checkpoint by removing ubiquitin from H2A at sites of DNA damage. USP3 is associated with chromatin, suggesting a role in regulating chromatin structure and function.
USP3 is also known as SIH003, UBP.
