VOPP1
Description
The VOPP1 (VOPP1 WW domain binding protein) is a protein-coding gene located on chromosome 7.
VOPP1 enhances the transcriptional activity of NFKB1 by promoting its nuclear translocation, DNA-binding, and subsequent apoptotic response when overexpressed. VOPP1 may also sequester WWOX in lysosomal vesicles, thus regulating WWOX's function as a tumor suppressor.
VOPP1 is also known as ECOP, GASP, WBP1L2.
Associated Diseases
- Rieger anomaly
- iridocorneal endothelial syndrome
- posterior amorphous corneal dystrophy
- isolated ectopia lentis
- X-linked corneal dermoid
- posterior polymorphous corneal dystrophy
- megalocornea
- cataract 50 with or without glaucoma
- congenital microcoria
- microphthalmia, isolated, with coloboma 10
- cancer
