WDFY2
Description
The WDFY2 (WD repeat and FYVE domain containing 2) is a protein-coding gene located on chromosome 13.
WDFY2 acts as an adapter protein, facilitating the interaction between PRKCZ kinase and its substrate VAMP2, leading to increased PRKCZ-dependent phosphorylation of VAMP2. It positively regulates adipocyte differentiation by promoting AKT1-mediated phosphorylation and inactivation of the anti-adipogenetic transcription factor FOXO1. WDFY2 also plays a role in endosomal control of AKT2 signaling, being essential for insulin-stimulated AKT2 phosphorylation, glucose uptake, and phosphorylation of AKT2 substrates. Furthermore, it participates in transferrin receptor endocytosis.
WDFY2 is also known as PROF, WDF2, ZFYVE22.
Associated Diseases
- glycogen storage disease VI
- cancer
- CIDEC-related familial partial lipodystrophy
- demyelinating disease
- PLIN1-related familial partial lipodystrophy
- obesity due to melanocortin 4 receptor deficiency
- coronary artery disease, autosomal dominant 2
- hyperinsulinism due to INSR deficiency
- AKT2-related familial partial lipodystrophy
