WDR26
Description
The WDR26 (WD repeat domain 26) is a protein-coding gene located on chromosome 1.
WDR26 is a protein that in humans is encoded by the WDR26 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
WDR26 is a G-beta-like protein involved in cell signal transduction. It acts as a negative regulator in the MAPK signaling pathway and functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. WDR26 is a core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. It acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. WDR26 serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. It protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria. WDR26 also protects cells by promoting hypoxia-mediated autophagy and mitophagy.
WDR26 is also known as CDW2, GID7, MIP2, SKDEAS.
Associated Diseases
- Skraban-Deardorff syndrome
- Intellectual disability-seizures-abnormal gait-facial dysmorphism syndrome
