WFIKKN1
Description
The WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1) is a protein-coding gene located on chromosome 16.
WFIKKN1 encodes a secreted protein with several domains: a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two Kunitz domains, and an NTR domain. These domains are commonly associated with protease inhibition, suggesting that WFIKKN1 encodes a multivalent protease inhibitor that can regulate multiple serine proteases and metalloproteinases.
WFIKKN1 encodes a protein with multiple distinct protease inhibitor domains, suggesting it inhibits both serine proteases and metalloproteases.
WFIKKN1 is also known as C16orf12, RJD2, WFDC20A, WFIKKN.
Associated Diseases
- autosomal recessive spondylocostal dysostosis
- spondylometaphyseal dysplasia, A4 type
- Richieri Costa-da Silva syndrome
- Poland syndrome
- autosomal dominant spondylocostal dysostosis
- kyphomelic dysplasia
- thoracolaryngopelvic dysplasia
- Becker nevus syndrome
- mesomelic dysplasia, Kantaputra type
- metatropic dysplasia
