YTHDC2
Description
The YTHDC2 (YTH N6-methyladenosine RNA binding protein C2) is a protein-coding gene located on chromosome 5.
YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.
YTHDC2 is a 3'-5' RNA helicase that plays a crucial role in the male and female germline, facilitating the transition from mitotic to meiotic divisions in stem cells. It specifically recognizes and binds to N6-methyladenosine (m6A)-containing RNAs, which are found in mRNAs and some non-coding RNAs, impacting RNA processing efficiency and stability. YTHDC2 is vital for a successful meiotic program in the germline by regulating the levels of m6A-containing RNAs. It binds and promotes the degradation of m6A-containing mRNAs, a process that requires its 3'-5' RNA helicase activity and may be mediated by XRN1 exoribonuclease. This protein is essential for both spermatogenesis and oogenesis.
YTHDC2 is also known as CAHL, hYTHDC2.
Associated Diseases
- type 2 diabetes mellitus
- prostate cancer
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure, X-linked, 2
- male infertility with teratozoospermia due to single gene mutation
- isochromosomy Yp
- spermatogenic failure 61
- spermatogenic failure 73
- spermatogenic failure 74
