YTHDF1
Description
The YTHDF1 (YTH N6-methyladenosine RNA binding protein F1) is a protein-coding gene located on chromosome 20.
YTH domain family, member 1 is a protein that in humans is encoded by the YTHDF1 gene.
YTHDF1 specifically recognizes and binds to mRNAs containing N6-methyladenosine (m6A), a modification found at internal sites of mRNAs and some non-coding RNAs. This binding regulates the stability of these mRNAs, often promoting their degradation through interaction with the CCR4-NOT complex. YTHDF1, along with its paralogs YTHDF2 and YTHDF3, shares targets and acts redundantly to control mRNA degradation and cellular differentiation. It also plays a role in learning and memory by binding to m6A-containing neuronal mRNAs in the hippocampus. YTHDF1 further regulates axon guidance through binding to ROBO3 transcripts containing m6A. It acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells, potentially limiting anti-tumor responses. Additionally, YTHDF1 promotes the formation of phase-separated membraneless compartments, such as P-bodies and stress granules, by undergoing liquid-liquid phase separation upon binding to polymethylated mRNAs. These mRNA-YTHDF complexes then partition into various compartments, including P-bodies, stress granules, and neuronal RNA granules. YTHDF1 interacts with CNOT1, facilitating the recruitment of the CCR4-NOT complex, and also interacts with ribosomes, eIF3 (EIF3A or EIF3B), and YTHDF3.
YTHDF1 is also known as C20orf21, DF1.
