ZC3H7A
Description
The ZC3H7A (zinc finger CCCH-type containing 7A) is a protein-coding gene located on chromosome 16.
ZC3H7A is involved in the regulation of microRNA (miRNA) biogenesis. It specifically binds to the hairpins of certain miRNAs, such as MIR7-1, MIR16-2, and MIR29A, through recognition of a specific motif (3'-ATA(A/T)-5') located in the apical loop of these hairpins.
ZC3H7A is also known as HSPC055, ZC3H7, ZC3HDC7.
Associated Diseases
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- alpha thalassemia-intellectual disability syndrome type 1
- hemoglobin D disease
- dominant beta-thalassemia
- delta-beta-thalassemia
- hemoglobin E-beta-thalassemia syndrome
- hemolytic anemia due to adenylate kinase deficiency
