ZCWPW1
Description
The ZCWPW1 (zinc finger CW-type and PWWP domain containing 1) is a protein-coding gene located on chromosome 7.
ZCWPW1 acts as a dual histone methylation reader, specifically recognizing PRDM9-catalyzed histone marks H3K4me3 and H3K36me3. This protein plays a role in facilitating the repair of meiotic double-strand breaks (DSBs) induced by PRDM9. It is essential for male fertility and spermatogenesis, specifically required for meiosis prophase I progression in male germ cells but not in female germ cells.
ZCWPW1 is also known as ZCW1.
Associated Diseases
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 25
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure, X-linked, 2
- isochromosomy Yp
- isochromosomy Yq
- spermatogenic failure 63
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 48
- spermatogenic failure 61
- spinocerebellar ataxia type 32
