ZCWPW2

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Description

The ZCWPW2 (zinc finger CW-type and PWWP domain containing 2) is a protein-coding gene located on chromosome 3.

ZCWPW2 is a histone methylation reader protein that binds to different methylation states of lysine 4 on histone H3, including non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2), and trimethylated (H3K4me3). It exhibits a preference for binding in the following order: H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.

ZCWPW2 is also known as ZCW2.

Associated Diseases

• multiple sclerosis
• systemic lupus erythematosus
• cancer