ZFX
Description
The ZFX (zinc finger protein X-linked) is a protein-coding gene located on chromosome X.
The ZFX gene on the X chromosome encodes a protein involved in regulating gene expression. This protein belongs to the krüppel C2H2-type zinc-finger protein family, containing domains for DNA binding, nuclear localization, and transcriptional activation. It is structurally similar to a related gene on the Y chromosome (ZFY). Studies have shown that ZFX is essential for the self-renewal of embryonic and adult hematopoietic stem cells, acting as a key regulator of their maintenance. Multiple variations of the ZFX protein exist due to alternative splicing. The ZFX gene is associated with X-linked neurodevelopmental disorders.
ZFX is also known as MRXS37, ZNF926.
Associated Diseases
- familial primary pulmonary hypoplasia
- male infertility with teratozoospermia due to single gene mutation
- pyknoachondrogenesis
- spermatogenic failure 8
- partial chromosome Y deletion
- spermatogenic failure 51
- spermatogenic failure 65
- spermatogenic failure, X-linked, 3
- spermatogenic failure 39
- cancer
- spermatogenic failure 40
- spermatogenic failure 48
- spermatogenic failure 72
- spermatogenic failure 47
- spermatogenic failure 25
