ZFYVE1
Description
The ZFYVE1 (zinc finger FYVE-type containing 1) is a protein-coding gene located on chromosome 14.
Zinc finger FYVE domain-containing protein 1 (ZFYVE1) is a protein encoded by the ZFYVE1 gene in humans. The FYVE domain plays a role in recruiting proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. ZFYVE1 contains two tandem zinc-binding FYVE domains and displays a distribution primarily within the Golgi, endoplasmic reticulum, and vesicles. Alternatively spliced transcript variants have been identified, leading to two isoforms with different sizes.
ZFYVE1 plays a key role in lipid droplet (LD) formation, acting as a central regulator of lipid and energy homeostasis. It influences the morphology, size, and distribution of LDs, facilitating the formation of endoplasmic reticulum-lipid droplet (ER-LD) contacts. This interaction is mediated by a complex with RAB18 and ZW10. ZFYVE1 binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger domain.
ZFYVE1 is also known as DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1.
