ZNF683
Description
The ZNF683 (zinc finger protein 683) is a protein-coding gene located on chromosome 1.
ZNF683 is a transcription factor that regulates gene expression in various immune cell types, including tissue-resident memory T (Trm) cells, natural killer (trNK) cells, and natural killer T (NKT) cells. It plays a crucial role in the development, retention, and long-term establishment of these T-cell populations in non-lymphoid organs like the skin, gut, liver, and kidney. ZNF683 promotes the development and maintenance of these tissue-resident T-cell populations by suppressing the expression of genes that promote their migration out of these tissues. This function helps ensure a rapid immune response against reactivating infections or viral reinfection. ZNF683 also influences the differentiation of both thymic and peripheral NKT cells, regulating interferon-gamma (IFN-gamma) production and granzyme B production in these cells. It interacts with the transcriptional repressor PRDM1/BLIMP1 at gene promoter regions.
ZNF683 is also known as Hobit.
Associated Diseases
- Miyoshi myopathy
- cancer
- isolated agammaglobulinemia
- combined immunodeficiency with skin granulomas
- agammaglobulinemia 7, autosomal recessive
- common variable immunodeficiency
- immunodeficiency 18
- severe combined immunodeficiency due to IKK2 deficiency
- immunodeficiency, common variable, 4
- immunodeficiency 19
- Okt4 epitope deficiency
- idiopathic CD4 lymphocytopenia
- Cernunnos-XLF deficiency
- T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency
- severe combined immunodeficiency due to LAT deficiency
- combined immunodeficiency due to partial RAG1 deficiency
- immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia
- T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant
- combined immunodeficiency due to CD3gamma deficiency
- combined immunodeficiency due to ZAP70 deficiency
