ZNF93
Description
The ZNF93 (zinc finger protein 93) is a protein-coding gene located on chromosome 19.
ZNF93 is a transcription factor that plays a crucial role in repressing the activity of long interspersed nuclear element 1 (L1) retrotransposons. It achieves this by recognizing and binding to specific L1 sequences, thereby recruiting a repressive complex containing TRIM28/KAP1. However, ZNF93‘s ability to repress L1 activity is not uniform across all subtypes. It effectively binds to and silences the L1PA4, L1PA5, L1PA6, and a subset of L1PA3 subtypes. Notably, ZNF93 does not bind to L1PA7 or older subtypes, nor to the most recently evolved L1PA2 and L1Hs. Furthermore, approximately 50% of L1PA3 elements have lost their ZNF93-binding site, which explains why ZNF93 cannot repress their expression.
ZNF93 is also known as HPF34, HTF34, TF34, ZNF505.
Associated Diseases
- Shwachman-Diamond syndrome
- atypical hemolytic-uremic syndrome with C3 anomaly
- atypical hemolytic-uremic syndrome with I factor anomaly
- atypical hemolytic-uremic syndrome with MCP/CD46 anomaly
- atypical hemolytic-uremic syndrome with thrombomodulin anomaly
- tubulointerstitial kidney disease, autosomal dominant, 2
- atypical hemolytic-uremic syndrome with B factor anomaly
- congenital dyserythropoietic anemia type 4
- thrombocytopenia-absent radius syndrome
- microcephaly-cervical spine fusion anomalies syndrome
- paroxysmal nocturnal hemoglobinuria
- cancer
- laryngotracheoesophageal cleft
- pachyonychia congenita
